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蔡耿彰
BIOCADD : http://www.biocadd.com
Keng-Chang Tsai
E-mail : tkc@biocadd.com
E-mail : g894283@life.nthu.edu.tw
Cellphone : 0920411028
MSN : kctsai88@hotmail.com
Speciality :
0. Protein-ligand,
Protein-Glycan, Protein-Peptide interaction
Protein-Protein
interaction (Antibody-Antigen)
1. Computer Aided Drug Design (Docking & 3D-QSAR & De Novo )
2..Virtual High Throughtput Docking & Virtual High Content Docking
3. Bioinformatic
4. Structural Biology
5. Molecular Simulations
6. PhyBioChem
7. Physics
http://life.nthu.edu.tw/~g894283
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Education:
1996~2000 : B. S. Soochow University (Physics) http://www.scu.edu.tw/
2000~2005 : Ph.D. National Tsing Hua University (Life Sciense) http://life.nthu.edu.tw/
Experience:
2003~present : BIOCADD website http://www.biocadd.com
2004~2005 : Bio-Information Project Manager , Breadth Technology company http://www.breadth.com.tw
2005~present : Postdoctor , Taiwan Academia Sinica Genomics Research Center http://www.genomics.sinica.edu.tw/ch/
Teaching:
1. 台灣大學
結構生物學輔助之藥物設計(Structure-Based Drug Design) (2009)
結構輔助藥物設計實例研討
http://
www.csie.ntu.edu.tw/~nbsc/course/2009/G10.pdf
2.Workshop on System Biology and Computer-aided Drug Design in National
Chiao-Tung
University.
交通大學--系統生物平台應用與電腦輔助藥物設計暑期推廣碩士學分班 (2006) (2007) (2008) (2009)
http://life.nctu.edu.tw/~summercourse/2007/poster.php
http://life.nctu.edu.tw/~summercourse/2009/
3.Workshop on Nucleic acid and protein computer simulation
analysis in molecular examination
application in National Cheng-Kung University
成功大學--核酸和蛋白質電腦模擬分析在分子檢驗應用 (2006) (2007) (2008) (2009)
http://www.ncku.edu.tw/~cbst/summer.html
http://teach.med.ncku.edu.tw/medtech/molecule_%20diagnosis/course_ncku.htm
4. Workshop on Development Technology Platform for New Drug
Discovery.
新藥開發技術平台研修專班
(財團法人自強工業科學基金會) (2004)
http://edu.tcfst.org.tw
5. Workshop on Computer-aided Drug Design (The theory and
practice)
電腦輔助藥物設計教育課程-理論與實作
（台南科學工業園區國家高速網路與計算中心）(2002) (2003)
https://edu.nchc.org.tw/
. ..... ....
Book:
化工資訊與商情第三十七期目錄 藥物資訊學在藥物開發的應用
http://www.chemcenter.com.tw/chemicalmonthly/37.html
Publication:
NCBI PubMed : http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=Tsai,Keng-Chang
2009 Impact-Factor : Download
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24
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Wen WH, Wang SY, Tsai
KC, Cheng YS, Yang AS, Fang JM*, and
Wong CH,
Analogues of zanamivir with modified C4-substituents as the inhibitors
against the group-1 neuraminidases of influenza viruses.
Bioorg. Med. Chem. (2010) Apr 8. (in press) ( Download )
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23
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Ho CW, Popat S, Liu TW, Tsai KC,
An-Suei Yang AS, Lin CH*, Development of GlcNAc-configured Iminocyclitiols
as Potent and Selective N-Acetyl-beta-Hexosaminidase Inhibitors. ACS Chem Biol. (2010)
5(5):489-97 ( Download )
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22
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Tsai KC, Hsiao NW, Chen
YC, Wang CL, Lin CL, Li MY*,Wang BH*, A comparison of different
electrostatic potentials on prediction accuracy in CoMFA and CoMSIA
studies. Eur J Med Chem. (2010) 45(4):1544-51 (
Download )
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21
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Tsai KC, Teng LW, Shao
YM,
Chen YC, Lee YC, Li MY, Hsiao
NW*, The first pharmacophore model for potent NF-κB inhibitors.Bioorg.
Med. Chem. Lett. 19 (2009) 5665–9 ( Download )
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20
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Wang SY, Tseng CP, Tsai KC,
Chia-Fan Lin, Wen CY, Tsay HS, Naoya Sakamoto, Tseng CH7, Cheng JC*,
Bioactivity-guided screening identifies a potent anti-hepatitis C virus
compound pheophytin a from Lonicera hypoglauca Miq. Biochem
Biophys Res Commun. (2009) 385(2):230-5 ( Download )
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19
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Yang Q, Du LP, Tsai KC, Wang XJ, Li MY*, You QD*, Pharmacophore
Mapping for Kv1.5 Potassium Channel Blockers. QSAR Comb. Sci.
28, (2009),
No. 1, 59 – 71 ( Download )
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18
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Tsai KC, Wang SH, Hsiao NW, Li MY*, Wang BH*. The Effect of Different Electrostatic Potentials on
Docking Accuracy: A Case Study Using DOCK5.4. Bioorg. Med. Chem. Lett.
18 (2008) 3509–3512 (
Download )
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17
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Hsu HJ, Tsai
KC, Sun YK, Chang HJ, Huang YJ, Yu HM, Lin CH, Mao SS, Yang AS*.
Factor-Xa Active Site Subatrate Specificity with substrate Phage Display
and Computational Molecular Modeling. J.
Biol Chem. (2008) , 283(18):12343-53 ( Download ) (Co-first author .)
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16
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Shao YM, Yang WB, Kuo TH, Tsai KC, Lin
CH, Yang AS, Liang PH, Wong CH*, Design, Synthesis, and
Evaluation of Trifluoromethyl Ketones as Inhibitors of SARS-CoV 3CL
Protease, Bioorg Med Chem (2008), 16, 4652-4660.( Download )
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15
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Lu IL , Tsai KC,
Chiang YK, Jiaang WT, Wu SH, Mahindroo N, Chien CH, Lee SJ, Chen X, Chao
YS, Wu SY.*. A Three-Dimensional Pharmacophore Model for Dipeptidyl
Peptidase IV Inhibitors.
Eur
J Med Chem. 2008 Aug;43(8):1603-11(Download )
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14
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Shie JJ, Fang JM* , Wang SY, Tsai KC, Cheng YS, Yang AS, and Wong CH
Synthesis of Tamiflu and its Phosphonate Congeners Possessing Potent
Anti-Influenza Activity. J. Am. Chem.
Soc. 129(39),11892-3 (2007) ( Download )
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13
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Shao YM, Yang WB, Peng HP, Hsu MF, Tsai KC, Kuo TH, Wang Andrew HJ, Liang PH, Lin CH, Yang
AS*, and Wong CH* Structure-Based Design
and Synthesis of Highly Potent SARS-CoV 3CL Protease Inhibitors. Chem.Bio.Chem. 8,1654-1657(2007) (Download)(Support)
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12
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Tsai KC, Chen, S.Y.,
Liang, P.H., Lu, I.L., Mahindroo, N., Hsieh, H.P., Chao, Y.S., Liu, L.,
Liu, D., Lien, W., Lin TH* and Wu SY* " Discovery of a Novel Family of
SARS-CoV Protease Inhibitors by Virtual Screening and 3D-QSAR Studies"
J. Med. Chem. 49, 3485-3495. (2006) ( Download )
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11
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Lu IL, Mahindroo N, Liang PH, Peng YH, Kuo CJ,
Tsai KC, Hsieh HP, Chao YS, and Wu SY*.
"Structure-Based Drug Design and Structural Biology Study of Novel
Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main
Protease." J. Med. Chem. 24,
5154-61. (2006) ( Download )
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10
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Lin, T.H*., Chiu, S.H. and Tsai, K.C.
Supervised feature ranking using a genetic algorithm optimized artificial
neural network. J. Chem. Inf. Model. 46, 1604-1614. (2006) ( Download )
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09
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Wei HY, Tsai KC and Lin TH*
".Modeling Ligand-Receptor Interaction for Some MHC Class II HLA-DR4
Peptide Mimetic Inhibitors Using Several Molecular Docking and 3D QSAR
Techniques" J. Chem. Inf. Model.
45. 1343-51. (2005) ( Download )
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08
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Zheng ZL, Zuo ZY, Liu ZG, Tsai KC ,
Liu AF *, Zou GL " Construction of a 3D model of Nattokinase, a novel
fibrinolytic enzyme from Bacillus natto----A novel nucleophilic catalytic
mechanism for Nattokinase." J. Mol. Graph. Model. 23, 373-80. (2005) ( Download )
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07
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Du LP, Li MY, Tsai KC, You QD*,
and Xia L, "Characterization of binding site of closed-state KCNQ1
potassium channel by homology modeling, molecular docking, and
pharmacophore identification", Biochem. Biophys. Res. Commun. 332. 677-687. (2005) ( Download
)
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06
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Li MY, Tsai KC , and Xia L* , "
Pharmacophore identification of alpha\ 1A
-adrenoceptor antagonists " Bioorg. Med. Chem. Lett. 15,
657-664. (2005) ( Download )
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05
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Tsai KC and Lin,TH*,
"A ligand-based molecular modeling study on some matrix
metalloproteinase-1 inhibitors using several 3D QSAR techniques" J.
Chem. Inf. Comput. Sci. 44. 1857-1871 (2004) ( Download
)
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04
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Du LP, Tsai KC, Li MY, You QD*,
and Xia L, "The pharmacophore hypotheses of IKr potassium channel
blockers: novel class III antiarrhythmic agents" Bioorg. Med.
Chem. Lett. 14, 4771-4777 (2004) (Download )
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03
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Liu HC, Lyu PC, Leong MK, Tsai KC,
Hsiue GH*, "3D-QSAR Studies on PU3 Analogues by Comparative Molecular
Field Analysis." Bioorg. Med. Chem. Lett. 14, 731-734 (2004)
( Download )
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02
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Lin,TH*, Li,HT. and Tsai KC
"Implementing the Fisher's discriminant ratio in a k-means clustering
algorithm for feature selection and data set trimming." J. Chem.
Inf. Comput. Sci. 44, 76-87 (2003) ( Download )
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01
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Lin,TH*, Tsai KC and Lo,TC
"Homology modeling of the central catalytic domain of insertion sequence
ISLC3 isolated from Lactobacillus casei ATCC 393." Protein
Engineering, Design and Selection 16, 819-829 (2003) ( Download
)
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