蔡耿彰 BIOCADD : http://www.biocadd.com Keng-Chang Tsai E-mail : tkc@biocadd.com E-mail : g894283@life.nthu.edu.tw Cellphone : 0920411028 MSN : kctsai88@hotmail.com Speciality : 0. Protein-ligand, Protein-Glycan, Protein-Peptide interaction Protein-Protein interaction (Antibody-Antigen) 1. Computer Aided Drug Design (Docking & 3D-QSAR & De Novo ) 2..Virtual High Throughtput Docking & Virtual High Content Docking 3. Bioinformatic 4. Structural Biology 5. Molecular Simulations 6. PhyBioChem 7. Physics http://life.nthu.edu.tw/~g894283

Education:

1996~2000 : B. S. Soochow University (Physics) http://www.scu.edu.tw/
2000~2005 : Ph.D. National Tsing Hua University (Life Sciense) http://life.nthu.edu.tw/

Experience:

2003/03~present : BIOCADD website http://www.biocadd.com
2004~2005 : Bio-Information Project Manager , Breadth Technology company http://www.breadth.com.tw
2005/10~2011/7 : Postdoctor , Taiwan Academia Sinica Genomics Research Center http://www.genomics.sinica.edu.tw/
2011/08~present : Assistant Research Fellow, National Research Institute of Chinese Medicine,Taiwan. http://www.nricm.edu.tw/

Teaching:

1. 台灣大學 結構生物學輔助之藥物設計(Structure-Based Drug Design) (2009)
結構輔助藥物設計實例研討
http:// www.csie.ntu.edu.tw/~nbsc/course/2009/G10.pdf

2.Workshop on System Biology and Computer-aided Drug Design in Nationa Chiao-Tung University.
交通大學--系統生物平台應用與電腦輔助藥物設計暑期推廣碩士學分班 (2006) (2007) (2008) (2009) (2010) (2011)
http://life.nctu.edu.tw/~summercourse/2011/poster.php

3.Workshop on Nucleic acid and protein computer simulation analysis in molecular examination
application in National Cheng-Kung University
成功大學--核酸和蛋白質電腦模擬分析在分子檢驗應用 (2006) (2007) (2008) (2009)
http://www.ncku.edu.tw/~cbst/summer.html
http://teach.med.ncku.edu.tw/medtech/molecule_%20diagnosis/course_ncku.htm

4. Workshop on Development Technology Platform for New Drug Discovery.
新藥開發技術平台研修專班 (財團法人自強工業科學基金會) (2004)
http://edu.tcfst.org.tw

5. Workshop on Computer-aided Drug Design (The theory and practice)
電腦輔助藥物設計教育課程-理論與實作
（台南科學工業園區國家高速網路與計算中心）(2002) (2003)
https://edu.nchc.org.tw/

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Book:

化工資訊與商情第三十七期目錄 藥物資訊學在藥物開發的應用
http://catalog.digitalarchives.tw/Exhibition/Detail.jsp?OID=5036459

Publication:

NCBI PubMed : http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=Tsai,Keng-Chang

2010 Impact-Factor : Download

27	Shie JJ, Fang JM, Lai PT, Wen WH, Wang SY, Cheng YS, Tsai KC, Yang AS, Wong CH. A Practical Synthesis of Zanamivir Phosphonate Congeners with Potent Anti-influenza Activity. J. Am. Chem. Soc. (2011) 9;133(44):17959-65. (Download)
26	Yang FL, Yang YL, Liao PC, Chou JC, Tsai KC, Yang AS, Sheu F, Lin TL, Hsieh PF, Wang JT, Hua KF, Wu SH. Structure and immunological characterization of capsular polysaccharide of a pyrogenic liver abscess Klebsiella pneumoniae: activation of macrophages through Toll-like receptor 4. J. Biol Chem. (2011) 17;286(24):21041-51 (Download)
25	Zhang L, Tsai KC, Du LP, Fang H, Li MY*, Xu WF*. How to Generate Reliable and Predictive CoMFA Models. Curr. Med. Chem. (2011) 18(6):923-30 ( Download )
24	Wen WH, Wang SY, TsaiKC, Cheng YS, Yang AS, Fang JM*, and Wong CH, Analogues of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses. Bioorg. Med. Chem. (2010) 18(11):4074-84 ( Download )
23	Ho CW, Popat S, Liu TW, Tsai KC, An-Suei Yang AS, Lin CH*, Development of GlcNAc-configured Iminocyclitiols as Potent and Selective N-Acetyl-beta-Hexosaminidase Inhibitors. ACS Chem Biol. (2010) 5(5):489-97 ( Download )
22	Tsai KC, Hsiao NW, Chen YC, Wang CL, Lin CL, Li MY*,Wang BH*, A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies. Eur J Med Chem. (2010) 45(4):1544-51 ( Download )
21	Tsai KC, Teng LW, Shao YM, Chen YC, Lee YC, Li MY, Hsiao NW*, The first pharmacophore model for potent NF-κB inhibitors.Bioorg. Med. Chem. Lett. 19 (2009) 5665–9 ( Download )
20	Wang SY, Tseng CP, Tsai KC, Chia-Fan Lin, Wen CY, Tsay HS, Naoya Sakamoto, Tseng CH7, Cheng JC*, Bioactivity-guided screening identifies a potent anti-hepatitis C virus compound pheophytin a from Lonicera hypoglauca Miq. Biochem Biophys Res Commun. (2009) 385(2):230-5 ( Download )
19	Yang Q, Du LP, Tsai KC, Wang XJ, Li MY*, You QD*, Pharmacophore Mapping for Kv1.5 Potassium Channel Blockers. QSAR Comb. Sci. 28, (2009), No. 1, 59 – 71 ( Download )
18	Tsai KC, Wang SH, Hsiao NW, Li MY*, Wang BH*. The Effect of Different Electrostatic Potentials on Docking Accuracy: A Case Study Using DOCK5.4. Bioorg. Med. Chem. Lett. 18 (2008) 3509–3512 ( Download )
17	Hsu HJ, Tsai KC, Sun YK, Chang HJ, Huang YJ, Yu HM, Lin CH, Mao SS, Yang AS*. Factor-Xa Active Site Subatrate Specificity with substrate Phage Display and Computational Molecular Modeling. J. Biol Chem. (2008) , 283(18):12343-53 ( Download ) (Co-first author .)
16	Shao YM, Yang WB, Kuo TH, Tsai KC, Lin CH, Yang AS, Liang PH, Wong CH*, Design, Synthesis, and Evaluation of Trifluoromethyl Ketones as Inhibitors of SARS-CoV 3CL Protease, Bioorg Med Chem (2008), 16, 4652-4660.( Download )
15	Lu IL , Tsai KC, Chiang YK, Jiaang WT, Wu SH, Mahindroo N, Chien CH, Lee SJ, Chen X, Chao YS, Wu SY.*. A Three-Dimensional Pharmacophore Model for Dipeptidyl Peptidase IV Inhibitors. Eur J Med Chem. 2008 Aug;43(8):1603-11(Download )
14	Shie JJ, Fang JM* , Wang SY, Tsai KC, Cheng YS, Yang AS, and Wong CH Synthesis of Tamiflu and its Phosphonate Congeners Possessing Potent Anti-Influenza Activity. J. Am. Chem. Soc. 129(39),11892-3 (2007) ( Download )
13	Shao YM, Yang WB, Peng HP, Hsu MF, Tsai KC, Kuo TH, Wang Andrew HJ, Liang PH, Lin CH, Yang AS*, and Wong CH* Structure-Based Design and Synthesis of Highly Potent SARS-CoV 3CL Protease Inhibitors. Chem.Bio.Chem. 8,1654-1657(2007) (Download)(Support)
12	Tsai KC, Chen, S.Y., Liang, P.H., Lu, I.L., Mahindroo, N., Hsieh, H.P., Chao, Y.S., Liu, L., Liu, D., Lien, W., Lin TH* and Wu SY* " Discovery of a Novel Family of SARS-CoV Protease Inhibitors by Virtual Screening and 3D-QSAR Studies" J. Med. Chem. 49, 3485-3495. (2006) ( Download )
11	Lu IL, Mahindroo N, Liang PH, Peng YH, Kuo CJ, Tsai KC, Hsieh HP, Chao YS, and Wu SY*. "Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease." J. Med. Chem. 24, 5154-61. (2006) ( Download )
10	Lin, T.H*., Chiu, S.H. and Tsai, K.C. Supervised feature ranking using a genetic algorithm optimized artificial neural network. J. Chem. Inf. Model. 46, 1604-1614. (2006) ( Download )
09	Wei HY, Tsai KC and Lin TH* ".Modeling Ligand-Receptor Interaction for Some MHC Class II HLA-DR4 Peptide Mimetic Inhibitors Using Several Molecular Docking and 3D QSAR Techniques" J. Chem. Inf. Model. 45. 1343-51. (2005) ( Download )
08	Zheng ZL, Zuo ZY, Liu ZG, Tsai KC , Liu AF *, Zou GL " Construction of a 3D model of Nattokinase, a novel fibrinolytic enzyme from Bacillus natto----A novel nucleophilic catalytic mechanism for Nattokinase." J. Mol. Graph. Model. 23, 373-80. (2005) ( Download )
07	Du LP, Li MY, Tsai KC, You QD*, and Xia L, "Characterization of binding site of closed-state KCNQ1 potassium channel by homology modeling, molecular docking, and pharmacophore identification", Biochem. Biophys. Res. Commun. 332. 677-687. (2005) ( Download )
06	Li MY, Tsai KC , and Xia L* , " Pharmacophore identification of alpha\ 1A -adrenoceptor antagonists " Bioorg. Med. Chem. Lett. 15, 657-664. (2005) ( Download )
05	Tsai KC and Lin,TH*, "A ligand-based molecular modeling study on some matrix metalloproteinase-1 inhibitors using several 3D QSAR techniques" J. Chem. Inf. Comput. Sci. 44. 1857-1871 (2004) ( Download )
04	Du LP, Tsai KC, Li MY, You QD*, and Xia L, "The pharmacophore hypotheses of IKr potassium channel blockers: novel class III antiarrhythmic agents" Bioorg. Med. Chem. Lett. 14, 4771-4777 (2004) (Download )
03	Liu HC, Lyu PC, Leong MK, Tsai KC, Hsiue GH*, "3D-QSAR Studies on PU3 Analogues by Comparative Molecular Field Analysis." Bioorg. Med. Chem. Lett. 14, 731-734 (2004) ( Download )
02	Lin,TH*, Li,HT. and Tsai KC "Implementing the Fisher's discriminant ratio in a k-means clustering algorithm for feature selection and data set trimming." J. Chem. Inf. Comput. Sci. 44, 76-87 (2003) ( Download )
01	Lin,TH*, Tsai KC and Lo,TC "Homology modeling of the central catalytic domain of insertion sequence ISLC3 isolated from Lactobacillus casei ATCC 393." Protein Engineering, Design and Selection 16, 819-829 (2003) ( Download )

update 2011/08/01