Curriculum Vitae
Minyong Li (李敏勇)
Current position : Adjunct Assistant
Professor of Chemistry
Work Address
Department of Chemistry,
Georgia State University,
PO Box 4098
Tel: 440-413-5545 (O)
E-mail : mli@gsu.edu
EDUCATION
Ph. D. :
June 2005, Department of Medicinal Chemistry,
China Pharmaceutical University, Nanjing, China
B. S. :
July 1995, Department of Pharmaceutics,
China Pharmaceutical University, Nanjing, China
ACADEMIC EXPERIENCES
October 2007 – present : Adjunct Assistant Professor, Department
of Chemistry, Georgia State Univeristy, Atlanta, GA 30303, USA
September 2005 – October 2007 : Postdoctoral Research Associate with Dr. Binghe Wang, Department of Chemistry, Georgia State Univeristy,
Atlanta, GA 30303, USA
June 2003 – September 2003 : Visiting Scholar with
Prof. Jinfen Lu and Prof. Lihe Zhang, National Research Laboratory of Natural
and Biomimetic Drugs, Peking University, Beijing 100083, China
RESRARCH INTERESTS
1.
Organic
Chemistry/Medicinal Chemistry: Rational Design, Synthesis, Biological
Evaluation and Structure-Activity Relationship Studies of Novel
Therapeutic Agents Targeted on Various Enzymes, G-Protein Coupled Proteins
(GPCRs) and Ion Channels
2. Bioorganic
Chemistry/Molecular Recognition: Development of Boronic Acid-Based Fluorescent
Sensors for the Recognition and Analysis of Molecules of Biological Importance
3. Computational Chemistry/ Computer-Aided Drug Design:
Identification of Potential Molecules using Quantative Structure-Activity Relationship (QSAR), Pharmacophore
Modeling and Molecular Docking
4. Biophysical Chemistry: Modeling and Simulation of Macromolecular
Structure, Enzyme Mechanism, and Ligand Binding using Molecular Mechanics (MM),
Molecular Dynamics (MD) and/or Quantum Mechanics (QM)
5. Biochemistry: Development
of Aptamers Using Systematic Evolution
of Ligands by Exponential Enrichment (SELEX) Approach Targeting to
Various Glycoproteins
Membership of Sigma Xi, the
Scientific Research Society (2006-present)
Outstanding Undergraduate Student Fellowship (1995-1999)
Reviewer for (1) FEBS Letters; (2) Bioorganic Medicinal Chemistry
Letters; (3) Bioorganic Medicinal Chemistry; (4) Acta Pharmacologica Sinica
FUNDINGS
COMBINE-ENGINEER:
A software tool for molecular design using protein structure-based quantitative structure activity
relationships, PI, EU Marie Curie Incoming International
Fellowships
(Proposal No. 022041), �145,186.39, October 1, 2005 – September 30, 2007 (Funded, but voluntarily declined)
PUBLICATION
LIST
Peer-Reviewed
Publications
1.
S. Jin, J.F. Wang, M.Y.
Li and B.H. Wang, Synthesis of A Series of Long-Wavelength Fluorescent Boronic Acid Reporters, Journal of Organic
Chemistry, 2007, in preparation
2.
N.T. Ni, J.F. Wang, M.Y. Li, H.T. Chou, C.D. Lu and B.H. Wang, Boronic acids can be
used for the sequestration of AI-2 related quorum sensing molecules, Organic Letters, 2007, in preparation.
3.
N.T. Ni, M.Y. LI, J.F. Wang and B.H. Wang, Recent Progress on Quorum Sensing Inhibitors, Medicinal Research
Reviews, 2007, in preparation
4.
L.P. Du, S.L. Zheng, M.Y. Li and B.H. Wang, Rational Design of Reactive Oxygen Species Biosensor, Organic
Letters, 2007, in preparation
5.
M.Y. Li, Y.J. Huang, B.H. Wang and P.C. Tai, Discovery of SecA Inhibitors by Docking-Based Virtual Screening, Journal
of Mecicinal Chemistry, 2007, in
preparation
6.
M.Y. Li, N.T. Ni, H.T. Chou, C.D. Lu and B.H. Wang, Structure-Based Discovery of First AI-2 Quorum Sensing Inhibitors,
Journal of Mecicinal Chemistry, 2007,
in preparation
7.
M.Y. Li, N.T. Ni, Y.Q. Zhang and B.H. Wang, Modeling the Excitation Wavelengths (λex) of Boronic Acid-Based
Fluorescent Biosensors Using UFS, MLR,
PLS and ASNN, Journal
of Fluorescence, 2007, in
preparation
8.
M.Y. Li
and B.H. Wang, Comparative Active Site Analysis of Quorum Sensing AI-2
Rreceptors, Bioorganic & Medicinal Chemistry Letters, 2007, in preparation.
9.
M.Y. Li, K.C. Tsai and B.H. Wang, The
Effect of Different Electrostatic Potentials on Ligand-Protein Docking Accuracy,
Bioorganic & Medicinal
Chemistry Letters, 2007, in preparation
10.
Q. Yang,
L.P. Du, X.J. Wang, M.Y. Li and Q.D. You, Kv1.5
Potassium Channel: A Homology Modeling and Molecular Docking Investigation, Journal of
Molecular Graphics and Modeling, 2007, in preparation
11. S.L. Zheng, G. Kaur, H. Wang, M.Y. Li,
M.
Macnaughtan, F.
Tian,
S.
Reid, X.
Yang, J.
Glushka, B.H.
Wang, H.M.
Ke and J.
Prestegard, Synthesis, SAR,
Molecular Modeling, and NMR Studies of Phenylalkyl Ketone Series as Highly
Potent and Selective PDE4D Inhibitors. Journal of Medicinal Chemistry,
2007, in review
12.
S. Jin, M.Y. Li and B.H. Wang, Rational Design, Synthesis and Evaluation of A Series of Boronic Acid Biosensors of Catecholamines, Chemical Communications, 2007, in review
13.
Q. Yang,
X.J. Wang, L.P. Du, M.Y. Li and Q.D. You,
Strategy for Atrial Fibrillation Therapy: Focusing on IKur
Potassium Channel, Expert Opinion on Therapeutic
Patents, 2007, in revised
14.
L.P. Du, M.Y. Li, Q. Yang, Y.Q. Tang, Q.D. You and L. Xia, Rational Design, Synthesis, Biological
Evaluation and Structure-Activity Relationship of Chromanol Derivatives as IKr
and IKs
Potassium Channel Dual Blockers, Journal of Medicinal
Chemistry, 2007, in review
15.
M.Y. Li, N.
Lin, Z. Huang, C. Altier
and B.H. Wang, Going after the “Sweet
Spot” in Selecting Aptamers for a Glycoprotein through the Incorporation of the
Boronic Acid Moiety, Angewandte Chemie
International Edition, 2007, in revised
16.
M.Y. Li and L. Xia, Rational Design, Synthesis, Biological Evaluation
and Structure-Activity Relationship Studies of Novel 1-Indanone α1-Adrenoceptor
Antagonists, Chemical Biology & Drug Design, 2007. 70(5): p. 461-4.
17.
M.Y. Li
and B.H. Wang, Towards Understanding the Structure
of H5N1 Nonstructural
Protein NS1 Effector Domain: A Molecular Modeling Study, Journal of Molecular Modeling, 2007. 13(12): p. 1237-44.
18.
L.P. Du, M.Y. Li, Q.D. You and L. Xia, A novel structure-based
virtual screening model for the hERG channel blockers. Biochemical and
Biophysical Research Communications, 2007. 355(4): p. 889-894.
19.
Y.L. Zhang, M.Y. Li,
20.
N. Lin, J. Yan, Z. Huang, C. Altier, M.Y. Li, N. Carrasco, M. Suyemoto,
L. Johnston, S.M. Wang, Q. Wang, H. Fang, J. Caton-Williams and B.H. Wang, Design
and synthesis of boronic-acid-labeled thymidine triphosphate for incorporation
into DNA. Nucleic Acids Research, 2007. 35(4): p. 1222-1229.
21.
H. Fang, M.Y. Li and L. Xia, Pharmacophore-guided design, synthesis
and evaluation of quinazoline-arylpiperazines as new α1-adrenoceptor
antagonists. Chinese Chemical Letters, 2007. 18(1): p. 41-44.
22.
F. Liu, Q.D. You, M.Y. Li, W.B. Shen and L. Xia, Convenient and rapid
preparation of indene dimers from indenes or indanols. Organic Preparations
and Procedures International, 2006. 38(5): p. 490-494.
23.
M.Y. Li and B.H. Wang, Computational studies of H5N1 hemagglutinin
binding with SA-α-2, 3-Gal and SA-alpha-2, 6-Gal. Biochemical and
Biophysical Research Communications, 2006. 347(3): p. 662-668. (Top 10
Hottest Articles on Biochemical and Biophysical Research Communications on July
– September 2006)
24.
M.Y. Li, H. Fang and L. Xia, Pharmacophore-based design, synthesis,
biological evaluation, and 3D-QSAR studies of aryl-piperazines as α1-adrenoceptor
antagonists. Bioorganic & Medicinal Chemistry Letters, 2005. 15(13):
p. 3216-3219.
25.
M.Y. Li, J.F. Lu and L. Xia, Receptor-based molecular modeling study
on antagonist-bound human α
26.
M.Y. Li, K.C. Tsai and L. Xia, Pharmacophore identification of α
27.
L.P. Du, M.Y. Li, K.C. Tsai, Q.D. You and L. Xia, Characterization of
binding site of closed-state KCNQ1 potassium channel by homology modeling,
molecular docking, and pharmacophore identification. Biochemical and
Biophysical Research Communications, 2005. 332(3): p. 677-687.
28.
H. Fang, M.Y. Li, L.
Xia, Z.Z. Jiang and Z.Z. Lu, Design and synthesis of novel
aryloxyalkyl-arylpiperazine derivatives as α
29.
B. Wu, M.Y. Li, Z.Z.
Jiang and L. Xia, Design, synthesis and 3D-QSAR study of 2-[N
'-(2-aryloxyethyl)piperazinomethyl]-benzoxazole series as α1-adrenoceptor antagonists. Acta Chimica Sinica, 2004. 62(15): p. 1430-1436.
30.
B. Wu, M.Y. Li, Z.Z. Jiang and L. Xia, Design, synthesis and 3D-QSAR
study of N-substituted-3-indolyl-acetamide series as α1-adrenoceptor
antagonists. Chinese Journal of Organic Chemistry, 2004. 24(12): p.
1587-1594.
31.
L.P. Du, K.C. Tsai,
M.Y. Li, Q.D. You and L. Xia, The pharmacophore hypotheses IKr
potassium channel blockers: novel class III antiarrhythmic agents. Bioorganic & Medicinal Chemistry Letters,
2004. 14(18): p. 4771-4777.
32.
M.Y. Li, L.P. Du, B. Wu and L. Xia, Self-organizing molecular field
analysis on α
Patents and Patent Filings
1.
B.H. Wang, M.Y. Li and Z. Huang, Nucleotides
including boronic acid groups, Polynucleotides including boronic acid groups,
aptamers including boronic acid groups, and methods or preparation of each, US Patent in filing
2.
B.H. Wang, N.T. Ni, M.Y. Li, Chung-Dar Lu and
Han-Ting Chou, Compositions
for Regulating Bacteria, Methods of Regulating Bacteria, and the Like, US Patent in filing.
3.
Q.D. You,
L.P. Du, M.Y. Li and L. Xia, A Chroman Compound,
Processes for Its Preparation, and Its Pharmaceutical
4.
Q.D. You,
L.P. Du,, M.Y. Li and L. Xia, Preparation
of 2,3-dihydrobenzopyran derivatives as antiarrhythmics, CN 1944428, Oct. 17, 2006
5.
Q.D. You,
L.P. Du, M.Y. Li and L. Xia, Preparation
and application of aromatic formylpiperazine compound used in medicines for
treating arrhythmia, CN 1944424, Oct. 17, 2006
6.
Q.D. You, L.P. Du, Q. Yang, M.Y. Li and L. Xia, Preparation of indole alkyl amine compounds
and application in medicines, CN 1944404, Oct. 17, 2006
7.
Q.D. You, L.P. Du, Q. Yang, M.Y. Li and L. Xia, Preparation and application of benzimidazole
compounds, CN 1944416, Oct. 17, 2006
Contributions to books
1.
M.Y. Li and L. Xia, Progress in Structure-Based
Molecular Design for α1-Adrenoceptor Antagonists, In Progress in Medicinal Chemistry, Vol. 6,
Chemical Industry Press, 2007, 1-26.
2.
L. Xia and M.Y. Li, The Progress on the Rational Drug Design for
the Treatment of Benign Prostaic Hyperplasia, In Frontier on Pharmaceutical Science, Vol. 2004, China Medical
Science and Technology Press, 2005,
185-215.
Meeting papers
1.
M.Y. Li and L. Xia, Rational Design, Synthesis and Biological Studies of
1-Indanone α1-Adrenoceptor Antagonists, the 5th International
Symposium for Chinese Medicinal Chemists, 2006, Nanjing,
China (poster presentation).
2.
L.P. Du, M.Y. Li, Q.D. You and L. Xia, Rational
design, synthesis and biological studies of novel chromene IKr and IKs dual blockers as
Class Ⅲ
Antiarrhythmic Agents, The 7th Sino-Japan Joint Symposium on Drug Design
and Development, 2005, Hanzhou,
China (oral presentation)
3.
M.Y. Li, J.F. Lu and L. Xia, A Molecular Modeling Study on Antagonist-Bound
Human α
4.
M.Y. Li and L.
Xia, A Rational Drug Design, Synthesis and Biological Activity Study on
Phenylpiperazine Derivatives as α1-Adrenoceptor Antagonists, China Pharmaceutical Association Annual
Meeting, 2004, Kunming, China (oral
presentation)
5.
M.Y. Li, H.
Fang, L. Xia and B.
Wu, 3D Quantitative Structure-Activity Realationship Study on Phenylpiperazine
Series as α1-Adrenoceptor Antagonists, China Pharmaceutical Association
Annual Meeting, 2002, Guilin, China
(poster presentation)